Fibroid pain during pregnancy can vary significantly depending on the size, number, and location of the fibroids, as noted by USA Fibroid Centers. During the first trimester, rapid hormone changes may cause fibroids to grow or shift, sometimes leading to pelvic or lower-back pain. In the second and third trimesters, the expanding uterus can place additional pressure on fibroids, triggering discomfort, cramping, or even acute pain if a fibroid undergoes degeneration. https://governmentgrantsamerica.blogspot.com/2025/11/understanding-fibroid-pain-during.html