Cellulose is found to be present in bacteria apart from the cell wall of green plants. The plant cellulose is often associated with lignin, pectin, hemicellulose, and other biogenic products, which influences the purity of cellulose. Therefore, microbial cellulose is considered as a source of pure cellulose, which is usually synthesized by the bacteria. Though the bacterial cellulose (BC) and plant fiber have different physical and chemical properties, they have a similar structure with two discrete cellulosic subunits I and II. It has high purity and distinct physicochemical characteristics, which has been used in various applications such as food industries, bio-medical sectors, and biobased polymers and nanocomposites preparation. With the increasing awareness of environmental sustainability, BC as a biobased material with high performance at affordable costs has been used in the food and food packaging sectors and biomedical applications. They are with high biocompatibility and biodegradability and easier to be functionalized. This natural hydrogel is found to have promising applications as bacterial cellulose composite with antimicrobial and antibiofilm activities.